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Technology

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Improves Quality of Life
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Strong Track Record of Safety & Effectiveness
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Easy to Use Device
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Breaking the Cycle of Excess Mucus, Inflammation, and Infection

ARINA·1 is a novel, at-home nebulized therapy that restores overall lung health by clearing mucus, reducing inflammation, and inhibiting bacterial growth. Our initial focus is on lung transplant, non-CF bronchiectasis (NCFBE), and chronic bronchitis (CB).

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Breaking the Vicious Cycle of Mucus in the Lungs

Excess mucus and pathological inflammation damage the airway, leaving it more susceptible to infection.

Thick Mucus Accumulates in Airways
Inflammation Damages Airway
Increased Risk of Bacterial Infection
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Over 25 patient-years of clinical safety and efficacy data supported
by clean chronic toxicology data.

How ARINA·1 Breaks the Cycle

Improves Mucociliary Clearance
Improves
Mucociliary Clearance
  • Thins mucus viscosity

  • Improves ciliary function

  • 8x more effective than hypertonic saline for clearing mucus

Decreases Pathological Inflammation
Decreases
Inflammation
  • Decreases inflammation comparably to potent steroids without harmful side effects

  • No evidence of neutropenia or increased risk of infection, even with long-term use

Inhibits Bacterial Growth
Inhibits
Bacterial Growth
  • Direct anti-bacterial effect

  • Broad-spectrum activity without promoting bacterial resistance

    • Inhibits Gram positive (e.g., MRSA), Gram negative (e.g., Pseudomonas aeruginosa), and NTM bacteria (e.g., M. abscessus, MAC)

Meet ARINA·1

  • Improves lung health by delivering ions directly to the airway

  • Restores innate immune defenses

  • Proven to decrease mucus, inflammation, and infection

  • Nebulized, at-home therapy

  • 10-15 minute nebulization

  • Portable device

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eFlow Partnering eBase by Pari

Benefits of the PARI eFlow Nebulizer

  • Short inhalation times

  • Quiet for discreet use at home, in the office, or during travel

  • Light, small, and portable

  • Conveniently powered with AC/wall outlet or battery operation
  • Easy to clean, can be disinfected at home

Target Indications

In our target diseases, thick mucus often accumulates in the lungs and cannot be effectively cleared out of the airways, which leads to mucus plugging and difficulty breathing.

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Pipeline

Pre-Clinical
Phase 1
Phase 2
Phase 3
Patient Enrollment

* = Investigator-sponored

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