Improves Quality of Life
Strong Track Record of Safety & Effectiveness
Easy to Use Device
Breaking the Cycle of Excess Mucus, Inflammation, and Infection
ARINA·1 is a novel, at-home nebulized therapy that restores overall lung health by clearing mucus, reducing inflammation, and inhibiting bacterial growth. Our initial focus is on individuals with prevention of BOS progression in lung transplant, non-CF bronchiectasis (NCFBE), and nontuberculous mycobacterial lung disease (NTM-LD).
Breaking the Vicious Cycle of Mucus in the Lungs
Excess mucus and pathological inflammation damage the airway, leaving it more susceptible to infection.
Thick Mucus Accumulates in Airways
Inflammation Damages Airway
Increased Risk of Bacterial Infection
Over 25 patient-years of clinical safety and efficacy data supported
by clean chronic toxicology data.
How ARINA·1 Breaks the Cycle
Thins mucus viscosity
Improves ciliary function
8x more effective than hypertonic saline for clearing mucus
Decreases inflammation comparably to potent steroids without harmful side effects
No evidence of neutropenia or increased risk of infection, even with long-term use
Direct anti-bacterial effect
Broad-spectrum activity without promoting bacterial resistance
Inhibits Gram positive (e.g., MRSA), Gram negative (e.g., Pseudomonas aeruginosa), and NTM bacteria (e.g., M. abscessus, MAC)
Improves lung health by delivering ions directly to the airway
Restores innate immune defenses
Proven to decrease mucus, inflammation, and infection
Nebulized, at-home therapy
10-15 minute nebulization
Benefits of the PARI eFlow Nebulizer
Nebulizers are designed to be easy to use and quiet – do not disrupt others in the house, easy to transport.
Short inhalation times
Silent operation for discreet use
Light, small, portable – can easily fit in a bag or jacket pocket
Conveniently Powered with AC/wall outlet or battery operation
Easy to clean, can be disinfected at home, offering a high degree of hygienic safety.
In our target diseases, thick mucus often accumulates in the lungs and cannot be effectively cleared out of the airways, which leads to mucus plugging and difficulty breathing.